DOI: 10.18129/B9.bioc.sigsquared    

This is the development version of sigsquared; for the stable release version, see sigsquared.

Gene signature generation for functionally validated signaling pathways

Bioconductor version: Development (3.9)

By leveraging statistical properties (log-rank test for survival) of patient cohorts defined by binary thresholds, poor-prognosis patients are identified by the sigsquared package via optimization over a cost function reducing type I and II error.

Author: UnJin Lee

Maintainer: UnJin Lee <unjin at>

Citation (from within R, enter citation("sigsquared")):


To install this package, start R (version "3.6") and enter:

if (!requireNamespace("BiocManager", quietly = TRUE))
BiocManager::install("sigsquared", version = "3.9")

For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:



PDF R Script SigSquared
PDF   Reference Manual


biocViews Software
Version 1.15.0
In Bioconductor since BioC 3.1 (R-3.2) (3.5 years)
License GPL version 3
Depends R (>= 3.2.0), methods
Imports Biobase, survival
Suggests RUnit, BiocGenerics
Depends On Me
Imports Me
Suggests Me
Links To Me
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Source Package sigsquared_1.15.0.tar.gz
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Mac OS X 10.11 (El Capitan) sigsquared_1.15.0.tgz
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