DOI: 10.18129/B9.bioc.DEComplexDisease    

This is the development version of DEComplexDisease; for the stable release version, see DEComplexDisease.

A tool for differential expression analysis and DEGs based investigation to complex diseases by bi-clustering analysis

Bioconductor version: Development (3.8)

It is designed to find the differential expressed genes (DEGs) for complex disease, which is characterized by the heterogeneous genomic expression profiles. Different from the established DEG analysis tools, it does not assume the patients of complex diseases to share the common DEGs. By applying a bi-clustering algorithm, DECD finds the DEGs shared by as many patients. In this way, DECD describes the DEGs of complex disease in a novel syntax, e.g. a gene list composed of 200 genes are differentially expressed in 30% percent of studied complex disease. Applying the DECD analysis results, users are possible to find the patients affected by the same mechanism based on the shared signatures.

Author: Guofeng Meng

Maintainer: Guofeng Meng <menggf at>

Citation (from within R, enter citation("DEComplexDisease")):


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if (!requireNamespace("BiocManager", quietly=TRUE))
BiocManager::install("DEComplexDisease", version = "devel")


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biocViews Clustering, DNASeq, DifferentialExpression, FunctionalGenomics, GeneExpression, Software, WholeGenome
Version 1.1.0
License GPL-3
Depends R (>= 3.3.3)
Imports Rcpp (>= 0.12.7), DESeq2, edgeR, SummarizedExperiment, ComplexHeatmap, grid, parallel, BiocParallel, grDevices, graphics, stats, methods, utils
LinkingTo Rcpp
Suggests knitr
Depends On Me
Imports Me
Suggests Me
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